CellVoyager High-Content Analysis System CQ3000 can acquire high-resolution 3D images at high speed while culturing cells.
CQ3000 can be combined with options according to the intended use to provide a system depending on your objectives.
CQ3000 System Highlights
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Excitation laser wavelength |
405nm、488nm、561nm、640nm |
| Objective lens | 2x、4x 、10x、20x 、40x、60x (Dry 、Water immersion、Long working distance) |
| Camera | High-sensitivity sCMOS camera (up to 2 units) |
| Autofocus | Laser autofocus |
| Observation method | Confocal image, Wide-field image*1 |
| Software (Option) |
High Content Analysis Software CellPathfinder |
*1 Can be acquired when Uniformizer option is selected.
Make way for high-performance HCA optimized for laboratories!
High NA immersion lens for high quality imaging, Uniformizer for uniform and efficient imaging of the entire FOV, and a second camera for simultaneous imaging of two channels can be selected according to the application.
High-resolution images that hold tons of information
- Water immersion lens captures clear images with a high SNR.
- In addition to fine observation via high magnification, it can accurately analyze images even with FOVs smaller than before due to the high-NA lens.
Our high-NA 20x water immersion lens developed in-house allows for image resolutions higher than a 20x dry lens. You can use 40x and 60x for efficient image analysis.
Imaging example for a spheroid
20x WI lens allows for deeper imaging with high SNR.
High throughput imaging via simple operation
Throughput comparison when using the 2nd camera option.
Detects two colors at the same time, so acquisition time is reduced.
In addition, if confocal performance is unnecessary such as during low magnification imaging, widefield imaging can further shorten the exposure time.
When it comes to Yokogawa, it’s all about live-cell imaging
CQ3000 achieves culturing and imaging while maintaining the same environment as a conventional CO2 incubator.
It’s not only environmentally friendly, but it also minimizes the impact on cells.
Details
Analysis software: High content analysis system CellPathfinder(Option)
The intuitive, easy-to-use interface guides the user from analyzing thousands of image data in various angles to visualize the result by generating numerous graph types.
In addition, the Machine Learning and Deep Learning function increase the target recognition capability dramatically. It is also ideal for the analysis with the complexity and high-degree-of-difficulty such as analyzing the data from 3D culture and live-cell imaging.
The CellPathfinder software is a powerful tool for HCA.
Machine learning
Software learns the features of the sample objects collected by users.
3D analysis
Label-free analysis
Wide-field*1 function is a powerful tool to analyze unstained bright field samples.
*1 Can be acquired when Uniformizer option is selected.
Specifications
| Optics | Microlens enhanced dual wide Nipkow disk confocal, Transmitted illumination |
|---|---|
| Fluorescence |
Laser: Up to 4 colors Standard: 488 nm, 561 nm Option: 405 nm, 640 nm |
| Transmitted illumination | Bright-field LED light |
| Camera | High-sensitivity sCMOS Max. 2 units, simultaneous excitation of 2 wavelengths Number of effective pixels: 2000 x 2000 pixels Field of view size: 13.0 x 13.0 mm |
| Objective lens | Max. 6 lenses (Included max. 2 water immersion lenses) Dry: 2x, 4x, 10x, 20x, 40x , 60x Long working distance: 20x, 40x Water immersion: 20x, 40x, 60x |
| Water supply function for immersion lens | Automatic supply |
| Flat-top beam shaper（Option） | Uniformizer |
| Sample vessel | Microplate (6, 12, 24, 48, 96, 384, 1536 wells), glass slides*2, cover glass chamber*2, 35 mm dish*2 |
| Stage incubator | Temperature control range 35 ~ 39 °C Settable temperature resolution: 0.1 °C Time stability : ±0.2 °C Spatial stability :±1 °C (at an ambient temperature of 21 ~ 25 °C) Humidity holding Automatic water supply function for incubator |
| Autofocus | Laser autofocus, Image-based autofocus |
| Fast time-lapse (Option) | Max.100fps , Simultaneous dual wavelength excitation imaging |
| Analysis software（CellPathfinder) | Granule analysis, Neurite analysis, Nuclear morphology analysis, Nuclear translocation analysis, Membrane translocation analysis, Machine learning, Label-free analysis, 3D analysis, Texture analysis, Deep Learning, etc. |
| Other features | Self-diagnosis function, CQ Analysis |
| Size・Weight | Main unit W1031 mm x D401 mm x H600 m 84 kg Main unit (with Uniformizer or 2nd camera) W1177 mm x D401 mm x H600 mm 102 kg Utility box W275 mm x D432 mm x H298 mm 17.6 kg Gas mixer W275 mm x D432 mm x H298 mm 9.3 kg Workstation W176.5 mm x D452.1 mm x H417.9 mm 21.7 kg |
| Operating environment | 15 ~ 30°C, 30 ~ 70% RH, no condensation |
| Power consumption | Main unit and Utility box : 100 - 240 VAC, 400 VAMax Gas Mixer : 100 - 240 VAC, 60 VAMax Workstation : 100 - 240 VAC, 750 VAMax |
*1 Can be acquired when Uniformizer option is selected.
*2 Sample Holder option is needed.
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CellActivision
CellActivision uses Machine Learning Technology and a unique digital filter to recognise cells or colonies directly from label free images. CellActivision can also classify and quantify these cells by the use of sample libraries which are easily prepared by the user.
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CellPathfinder
Cell imaging software supports label-free samples and provides multiple graphing options with a streamlined, easy-to-use interface.
Resources
Videos
In this webinar, Professor Jonny Sexton discusses a pipeline, developed in the Sexton lab, for the quantitative high-throughput image-based screening of SARS-CoV-2 infection to identify potential antiviral mechanisms and allow selection of appropriate drug combinations to treat COVID-19. This webinar presents evidence that morphological profiling can robustly identify new potential therapeutics against SARS-CoV-2 infection as well as drugs that potentially worsen COVID-19 outcomes.
News
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Press Release Jan 31, 2024 Yokogawa Introduces CellVoyager High-Content Analysis System CQ3000
- For greater efficiency in drug discovery and regenerative medicine R&D, and the swift commercialization of new drugs -
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