Prof. Melanie Bailey and her group at the University of Surrey, UK, have used Yokogawa’s Single Cellome™ System SS2000 to enable single-cell LC/MS analysis from living cells, a technique that had been a challenge to achieve. By combining the highly accurate and gentle cell sampling technique of the SS2000 with liquid chromatography mass spectrometry technology, a revolutionary method for lipidomics analysis from ultra-low volume samples from living cell cultures was established. In this study, lipid profiles were stably read from individual pancreatic cancer cells, and this data was successfully correlated with the live cell imaging data also obtained by Yokogawa’s SS2000. This is a new milestone in lipidomics analysis and an innovative research achievement that overcomes the challenges present with other methods.
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Industries
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Pharmaceutical
Under continual pressure to increase profitability, maintain government compliance, and meet emerging market opportunities, the pharmaceutical manufacturing industry faces unique challenges that require unique solutions. As one of the world’s leading industrial automation suppliers, Yokogawa is poised and prepared to deliver those solutions, creating individualized lean manufacturing techniques that deliver consistent, measurable results.
Related Products & Solutions
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Single-cell and Subcellular Sampling System
The SS2000 is a dual microlens spinning disk confocal microscope for live-cell, high-content imaging which can sample adherent single cells and subcellular material while ensuring the preservation of spatial, morphological, and temporal information.
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Life Science
Yokogawa’s sensitivity and precision solutions enable rapid and accurate measurements, empowering groundbreaking research, accelerating drug discovery, and optimizing bio-production at scale.
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Single-Cell Analysis Solutions Single Cellome™
We are developing cell handling technology for single-cell and live cells. SU10 provides selective, minimally damaging automated nano-point delivery. SS2000 provides automatically subcellular sampling based on confocal microscopy technology.
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