Life Science

Early stage embryo

Our microscopy and life sciences solutions are designed to support applications from basic research to drug discovery and pre-clinical trials.

Yokogawa’s high content analysis systems and dual spinning disk confocal technologies are used in regenerative medicine, pharmaceutical research, and precision medicine to deliver rapid, high-resolution live cell imaging.

OpreX Informatics Manager

Yokogawa Electric's OpreX Informatics Manager is an information-integrated solution that goes beyond electronic lab notebooks by optimizing human and material resource management in terms of skills and scheduling.

See More
FlowCam: Flow Imaging Microscopy

With the FlowCam you can analyze particles accurately, reliably and quickly using automated imaging technology to advance your research, increase productivity, and ensure quality.

See More

We post our information to the following SNSs.
Please follow us.

Yokogawa Life Science

•Twitter	@Yokogawa_LS
•Facebook	Yokogawa Life Science
•LinkedIn	Yokogawa Life Science
•YouTube	Life Science Yokogawa

Yokogawa's Official Social Media Account List

Social Media Account List

Principles of Spinning disk confocal

The most common conventional confocal microscopes use a single laser beam to scan a specimen, while the CSU scans the field of view with approximately 1,000 laser beams, by using microlens-enhanced Nipkow-disk scanning: in short, CSU can scan 1,000 times faster.

By using a disk containing microlens arrays in combination with the Nipkow disk, we have succeeded in dramatically improving the light efficiency and thus successfully made real-time confocal imaging of live cells possible.

The expanded and collimated laser beam illuminates the upper disk containing about 20,000 microlenses (microlens array disk). Each microlens focuses the laser beam onto its corresponding pinhole, thus, effectively increasing laser intensity through pinholes placed in the pinhole array disk (Nipkow disk).

With the microlens, backscattering of laser light at the surface of the pinhole disk can be significantly reduced, thus, dramatically increasing the signal to noise ratio (S/N) of confocal images.

About 1,000 laser beams passing through each of the pinholes fill the aperture of the objective lens, and are then focused on the focal plane. Fluorescence generated from the specimen is captured by the objective lens and focused back onto the pinhole disk, transmitted through the same holes to eliminate out-of-focus signals, deflected by the dichroic mirror located between microlens array disk and the Nipkow disk to split fluorescence signal from reflected laser, passed through emission filter and then focused into the image plane in the eyepiece or camera.

The microlens array disk and the Nipkow disk are physically fixed to each other and are rotated to scan the entire field of view at high speeds, thus, making it possible to view confocal fluorescent images in real-time through the eyepiece of the CSU head.

As compared to conventional single point scanning, multi beam scanning by the CSU requires a significantly low level of light intensity per unit area, which results in significantly reduced photo bleaching and phototoxicity in live cells.

Spinning Disk Confocal

microlens / fastsacnning / minimal photo bleach / high resolution

Microlens-enhanced Nipkow Disk Technology

Comparison of scanning method

Point Scanning
1 line scan time＝1[ms]
1000 lines/image
Scan lines＝1000 [lines]
1×1000＝1000 [ms]

Disk Scanning by CSU
Rotation Speed＝10000 [rpm]=41.7[rps]
30°Rotation/image
1÷( 41.7×30/360 )＝ 0.5 [ms]

February	18,2022	Sales Release : Single Cellome^TM System SS2000 We announce the sales release of Single Cellome System SS2000 on February 18th, 2022. Advantages Automatic sampling of specific intracellular components or whole cells High resolution images and imaging analysis using confocal microscopy Precise pipetting control of location works Sampling with location and morphology information Keeping cell activity via incubator functions Release Date Japan, North America, China, Europe: February 18th, 2022 It will be successively launched in other regions. Some countries are not eligible. Please contact us for the details. Click Here For More Info
February	15,2022	Sales release : Confocal Quantitative Image Cytometer CellVoyager CQ1 new option and latest software were released High-speed time-lapse option (100 fps), an even faster model is now available (paid option). The latest software (R1.07.01) is now available! Expected to improve environmental control for live cell imaging and increase throughput at low magnifications! Click Here For More Info
February	15,2022	Sales release : CellPathfinder new product and the latest software were released Subscription sales launched! Available to select necessary items from flexible license conditions. [Function], [Period] and [Support Style] are all selectable. Sales of Function Selective Products started Concept of [Necessary Function for When Needed] Available to offer Basic Pack with Options style. The latest software (R3.06.01) is now available! By down sampling, available to create more than 20,000x20,000 pixel of tyle images, and observe overall picture for checking. Expected to improve analysis speed when spatial resolution is not essentially required. Click Here For More Info
December	1,2021	Yokogawa Develops Single Cellome System SS2000 for Intracellular Sampling - A single-cell analysis solution that revolutionizes efficiency in drug discovery research by fully automating the collection of intracellular components and specific cells - Yokogawa Electric Corporation (TOKYO: 6841) announces that it has developed the Single Cellome™ System SS2000, a single-cell analysis solution that utilizes high-definition images captured with a confocal microscope to accurately collect samples of intracellular components and specific cells. ＜Cell sampling＞・High resolution imaging using confocal microscope ・Precisely　analyzing for localization of intracellular components by 3D imaging ・Accurately positioning by the X, Y, and Z directions ・Sampling that maintains the positional and morphological information of cells ＜Features of the SS2000＞・Automatic sampling of specific intracellular components or whole cells ・High resolution images and imaging analysis using confocal microscopy ・Precise pipetting control of location works ・Sampling with location and morphology information ・Keeping cell activity via incubator functions The SS2000 will be released to the Japan, US and China market in January 2022, with release in other markets such as Europe to follow at a later date. Press Release: Yokogawa Develops Single Cellome System SS2000 for Intracellular Sampling
November	18,2021	Yokogawa Acquires Insilico Biotechnology, Developer of Innovative Bioprocess Digital Twin Technology Yokogawa Electric Corporation acquire Insilico Biotechnology a developer and provider of bioprocess software and services. Press Release:Yokogawa Acquires Insilico Biotechnology, Developer of Innovative Bioprocess Digital Twin Technology
January	8,2021	Sales release : Advanced Control Bioreactor System BR1000 was released. The Advanced Control Bioreactor System BR1000 automates lab-scale mammalian cell culture with highly accurate real-time monitoring and advanced process control. Click Here For More Info
August	20,2020	Discovering Potential Covid-19 Therapies using High Content Screening Date: Wednesday August 26th 2020 Time: 12pm (EST) 9am (PST) 5pm (London) Abstract: In this webinar, Professor Jonny Sexton discusses a pipeline, developed in the Sexton lab, for the quantitative high-throughput image-based screening of SARS-CoV-2 infection to identify potential antiviral mechanisms and allow selection of appropriate drug combinations to treat COVID-19. This webinar presents evidence that morphological profiling can robustly identify new potential therapeutics against SARS-CoV-2 infection as well as drugs that potentially worsen COVID-19 outcomes. Click Here for Registration
June	5,2020	Sales release : High-throughput Cytological Discovery System CV8000 : 20x water immersion lens option was released. Click Here For More Info
March	18,2020	Sales release : Single-cell Analysis Solution Single Cellome Unit SU10 Click Here For More Info
January	20,2020	Sales release : High Content Analysis Software CellPathfinder update and Deep learning option was released. Deep learning function succeeded in dramatically improving by recognizing patterns in images to identify what the images show. Link to products　High Content Analysis Software CellPathfinder Find out more about Deep learning
January	15,2020	Society for Laboratory Automation and Screening (SLAS) 2020 January 25-29, 2020 Booth No. 1148 We will exhibit high content analysis system "CellVoyager CQ1". Link to products Confocal Quantitative Image Cytometer CQ1 -Poster- 1207-C: A Live Cell High Content Assay for Cellular Lipid Droplets January 28, 2:00-3:00 pm Find out more about SLAS 2020