Orthogonal and complementary techniques for subvisible particle characterization in biotherapeutics

Biopharmaceutical formulation research and development requires researchers to use multiple analytical techniques to measure a sample’s critical quality attributes (CQAs).

This webinar will discuss the concept of orthogonal and complementary techniques and why employing these is crucial to effectively characterize biotherapeutic samples. An example application is presented, using flow imaging microscopy (FIM) and light obscuration (LO) to analyze protein aggregation in an accelerated stability study.

The agenda focuses on:

• How to determine when different analytical techniques are orthogonal and/or complementary
• The additional information orthogonal and complementary techniques provide researchers about biotherapeutic samples
• An example of applying orthogonal and complementary techniques using FlowCam LO to assess the impact of stress conditions and surfactant on protein aggregation in a biotherapeutic