The Advanced Control Bioreactor System BR1000 automates lab-scale mammalian cell culture with highly accurate real-time monitoring and advanced process control.
In-line sensor for measuring glucose and lactate concentrations
Based on YOKOGAWA's original calibration model and instrumentation, the concentration of glucose and lactic acid in the culture medium can be measured in real-time and with high accuracy based on the absorption characteristics of near-infrared light.
In-line sensor to measure live cell density
Based on YOKOGAWA's original calibration model, the live cell density can be measured in real time from changes in the capacitance characteristics of the cell suspension. The unique calibration model also maintains high accuracy throughout the entire cell culture timeline, from seeding to high cell densities.
Soft sensor for estimating glucose consumption rates in real time
A model prediction and control algorithm processes the data obtained by the in-line sensors and outputs a highly accurate glucose consumption rate trend in real time.
Advanced control to automatically control glucose concentration
An advanced control algorithm designed specifically for cell culture provides accurate and automatic control of glucose based on in-line sensor values. Peristaltic pump systems dynamically deliver sterile glucose solution as needed to maintain the glucose set-point concentration value.
详细介绍
Features of the system
The instrument provides basic control of pH, temperature, and dissolved oxygen, a near-infrared sensor for monitoring cell activity, a viable cell density sensor, feed control, and data logger, all integrated into one complete system.
Extensive control functions and ease of use
Automated Cell Culture
The bioreactor system provides advanced process control driven by innovative hardware and software technologies to improve reproducibility and stability of cell culture conditions for better biopharmaceuticals.
Customization and remote support (optional)
Comes complete with a calibration model derivation tool that customizes and improves the accuracy of in-line sensors.
Provides the capability for real-time remote monitoring in a networked environment.
视频
Our approach is to leverage state-of-the-art technologies for real-time monitoring and predictive control that allow virtual environments where "digital twin" processes can provide distinct advantages.
新闻
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新闻 2021年2月24日 横河电机与ICQ Consultants签署生物制药业务合作协议
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新闻 2021年11月2日 横河电机收购创新型生物过程数字孪生技术开发商Insilico Biotechnology
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